Тезисы на 28 международный конгресс

Dynamics of psychological state was studied in 212 children with absences upon attaining medicamentous compensation. 69 children had atypical frontal absence(AFA) (34 females/35 males). Simplex absence(SA) was diagnosed in 143 children(70 females/73 males). First psychological assessment was administered 3-4 weeks after last seizure documented by EEG. Second assessment was taken in a year, third 3 years after remission; last one 5 years after effective anticonvulsant therapy, i.e. before planned anticonvulsants discontinuation.

Results: Intellect structure irregularity through attention functions disturbance, established without reliable difference in various absences by first and second assessment, varied reliably by the third assessment, which was still so in 5 years of absence compensation(Р<0,002). Notably 50 AFA-children in 69(72.5%) having attention disturbance, kept them in 46 cases(66.7%) 5 years after seizure compensation. SA-children didn’t show similar attention function recovery dynamics.  The disturbance was recorded reliably more rarely in the first assessment(Р<0.001):46 in 143(32.2%). The disturbance was still fully present 5 years after total seizure absence(44 in 143,i.e. 30.8%).

It appeared that memory’s impaired with equal frequency in AFA/SA-children both in first and second assessment. Memory recovered reliably better in SA-children. None of 46 AFA-children(66.7%) demonstrated memory improvement five years after seizure absence.
Conclusion: intellect prerequisites recovery after acute epileptic process compensation in AFA may serve as a criterion of brain functions ontogenesis recovery in children. Recovery of intellect prerequisite during SA compensation may not be a  reliable criterion for prediction of epileptic process compensation level and for discontinuation of anticonvulsant therapy.